Acquired severe aplastic anemia: progress and perplexity

Acquired severe aplastic anemia: progress and perplexity.

T HE PATHOPHYSIOLOGY and treatment of acquired severe aplastic anemia (ASAA) has been the subject of recent reviews.’2 Whether idiopathic or idiosyncratic, ASAA is a “likely-to-be-fatal” disease.3 However, it has long been recognized that some patients will recover spontaneously, and a few lucky ones may do so with surprisingly rapid restoration of hematopoiesis.35 The inherent unpredictability...

The treatment of severe acquired aplastic anemia.

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Acquired aplastic anemia.

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Aplastic Anemia - Diagnos tics and Therapy of Acquired Aplastic Anemia

Aplastic Anemia: Acquired and Inherited

Acquired aplastic anemia is a clinical syndrome in which there is a deficiency of red cells, neutrophils, monocytes, and platelets in the blood, and fatty replacement of the marrow with a near absence of hematopoietic precursor cells. Reticulocytopenia, neutropenia, monocytopenia, and thrombocytopenia, when severe, are life-threatening because of the risk of infection and bleeding, complicated ...